Structure
Velusetrag Biochemical
Velusetrag
Purity
>98% (HPLC)
Synonyms
Velusetrag; TD-5108; Velusetrag biochemical
Purity/Purification
>98% (HPLC)
Target
5-HT Receptor
Receptor
5-HT Receptor
Chemical Name
N-((1R, 3R, 5S)-8-((R)-2-hydroxy-3-(N-methylmethylsulfonamido)propyl)-8-azabicyclo[3.2.1]octan-3-yl)-1-isopropyl-2-oxo-1, 2-dihydroquinoline-3-carboxamide
SMILES
O=C(C1=CC2=C(N(C(C)C)C1=O)C=CC=C2)NC3CC(N4C[C@@H](O)CN(C)S(=O)(C)=O)([H])CCC4([H])C3
Molecular Formula
C25H36N4O5S
CAS Number
866933-46-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Velusetrag biochemical
Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors; displays >25-fold selectivity over other biogenic amine receptors, and no effect on hERG channels; increases the contractility of the canine antrum, duodenum and jejunum with higher potency than tegaserod, demonstrates robust in vivo activity in the guinea pig, rat and dog gastrointestinal tracts. Other Indication Phase 2 Clinical
Product Categories/Family for Velusetrag biochemical
References
1. Beattie DT, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul; 378 (1):139-47.
2. Smith JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul; 378 (1):125-37.
3. Manini ML, et al. Neurogastroenterol Motil. 2010 Jan; 22 (1):42-9, e7-8.
4. Long DD, et al. Bioorg Med Chem Lett. 2012 Oct 1; 22 (19):6048-52.
2. Smith JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul; 378 (1):125-37.
3. Manini ML, et al. Neurogastroenterol Motil. 2010 Jan; 22 (1):42-9, e7-8.
4. Long DD, et al. Bioorg Med Chem Lett. 2012 Oct 1; 22 (19):6048-52.
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Product Notes
The Velusetrag (Catalog #AAA3606296) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Velusetrag, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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