PHCCC Biochemical

PHCCC

Cat. Num. AAA3607371

• Purity: >98% (HPLC)
• Synonyms: PHCCC; PHCCC biochemical

• Purity/Purification: >98% (HPLC)

• Suitability: DMSO: >=32mg/mL (108.73mM)
• Target: 5-HT Receptor
• Receptor: mGluR1
• Chemical Name: (E)-7-(hydroxyimino)-N-phenyl-7, 7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide
• SMILES: C12(C(/C(=N/O)/c3ccccc3O1)C2)C(=O)Nc1ccccc1
• Molecular Formula: C17H14N2O3
• CAS Number: 179068-02-1
• Preparation and Storage: Store at -20 degree C; Stability: >=2 years; Shipping: Ice Pack

Structure

Related Product Information for PHCCC biochemical

PHCCC is a positive allosteric modulator ofmgluR4. PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. PHCCC reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. PHCCC showed neuroprotection against betaAP- andnMDA-toxicity in mixed cultures of mouse cortical neurons. This neuroprotection was additive to that induced by the highly efficaciousmgluR1 antagonist CPCCOEt and was blocked by MSOP, a group-IIImgluR antagonist. Our data provide evidence for a novel pharmacological site onmgluR4, which may be used as a target-site for therapeutics.

Product Categories/Family for PHCCC biochemical

Endocrinology/Hormones; Cancer

References

1.Marino MJ et al.Proc Natl Acad Sci U S A. 2003 Nov 11; 100 (23):13668-73.