Structure
CTEP Biochemical
CTEP
Purity
>98% (HPLC)
Synonyms
CTEP; RO4956371; RO-4956371; RO 4956371; CTEP biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=100mg/mL (255.25mM)
H2O: <0.1mg/mL
H2O: <0.1mg/mL
Target
5-HT Receptor
Receptor
mGluR5
Chemical Name
2-chloro-4-[2-[2, 5-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazol-4-yl]ethynyl]pyridine
SMILES
CC1=NC(C#CC2=CC=NC(Cl)=C2)=C(C)N1C1=CC=C(OC(F)(F)F)C=C1
Molecular Formula
C19H13ClF3N3O
CAS Number
871362-31-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CTEP biochemical
CTEP, also known as RO4956371, is a potent, long-acting, orally bioavailable allosteric antagonist ofmglu5 receptor with IC50 of 2.2nM. CTEP bindsmglu5 with low nanomolar affinity and shows >1000-fold selectivity when tested against 103 targets, including all knownmglu receptors. CTEP penetrates the brain with a brain/plasma ratio of 2.6 and displaces the tracer ABP688 in vivo in mice from brain regions expressingmglu5 with an average ED (50) equivalent to a drug concentration of 77.5 ng/g in brain tissue.
Product Categories/Family for CTEP biochemical
References
1. Lindemann L, et al. J Pharmacol Exp Ther, 2011, 339 (2), 474-486.
Similar Products
Product Notes
The CTEP (Catalog #AAA3607629) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CTEP, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
