Structure
EMD-281014 hydrochloride Biochemical
EMD-281014 hydrochloride
Purity
>98% (HPLC)
Synonyms
EMD-281014 hydrochloride; Pruvanserin; LSN2411347; LY-2422347; EMD-281014 hydrochloride biochemical
Purity/Purification
>98% (HPLC)
Target
5-HT Receptor
Receptor
5-HT Receptor
Chemical Name
7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile hydrochloride
SMILES
C1CN(CCN1CCC2=CC=C(C=C2)F)C(=O)C3=CC=CC4=C3NC=C4C#N.Cl
Molecular Formula
C22H22ClFN4O
CAS Number
443144-27-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for EMD-281014 hydrochloride biochemical
EMD-281014 hydrochloride ( (Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87nM, displays little to no affinity for 5-HT2C receptors (Ki=557nM), human D2 receptors and IKr channels; significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test; reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset. Sleep Disorder Discontinued
Product Categories/Family for EMD-281014 hydrochloride biochemical
References
1. Hamadjida A, et al. Neuropharmacology. 2018 Jun 30; 139:61-67.
2. Lauffer L, et al. J Pharmacol Exp Ther. 2016 Jul; 358 (1):39-49.
3. Patel JG, et al. Synapse. 2004 Apr; 52 (1):73-5.
4. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2006 Jun 15; 16 (12):3201-4.
2. Lauffer L, et al. J Pharmacol Exp Ther. 2016 Jul; 358 (1):39-49.
3. Patel JG, et al. Synapse. 2004 Apr; 52 (1):73-5.
4. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2006 Jun 15; 16 (12):3201-4.
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Product Notes
The EMD-281014 hydrochloride (Catalog #AAA3604512) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EMD-281014 hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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