Structure
JTT-551 Biochemical
JTT-551
Purity
>98% (HPLC)
Synonyms
JTT-551; JTT551; JTT 551; JTT-551 biochemical
Purity/Purification
>98% (HPLC)
Target
Protein Phosphatase/PTP
Receptor
Protein Phosphatase/PTP
Chemical Name
N-((5-(tert-butyl)thiazol-2-yl)methyl)-N-((4-(4-((4-(heptan-4-yl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)glycine
SMILES
CCCC(CCC)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=CSC(=N3)CN(CC4=NC=C(S4)C(C)(C)C)CC(=O)O
Molecular Formula
C34H43N3O3S2
CAS Number
776309-04-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for JTT-551 biochemical
JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR; JTT-551 exhibits clear selectivity against the other PTPs, increases the insulin-stimulated glucose uptake in L6 cells; enhances the IR phosphorylation of liver and reduces the glucose level in ob/ob mice, also shows a hypoglycaemic effect without an acceleration of body weight gain in db/db mice. Diabetes Phase 1 Discontinued
Product Categories/Family for JTT-551 biochemical
References
1. Fukuda S, et al. Diabetes Obes Metab. 2010 Apr; 12 (4):299-306.
2. Ito M, et al. J Diabetes Res. 2014; 2014:680348.
2. Ito M, et al. J Diabetes Res. 2014; 2014:680348.
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Product Notes
The JTT-551 (Catalog #AAA3605929) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JTT-551, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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