Structure
MK-0941 mesylate Biochemical
MK-0941 mesylate
Purity
>98% (HPLC)
Synonyms
MK-0941 mesylate; MK0941; MK-0941 mesylate biochemical
Purity/Purification
>98% (HPLC)
Target
Glucokinase
Receptor
Glucokinase
Chemical Name
3-((6-(ethylsulfonyl)-3-pyridinyl)oxy)-5-((1S)-2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide mesylate
SMILES
CCS(=O)(=O)C1=NC=C(C=C1)OC2=CC(=CC(=C2)C(=O)NC3=NN(C=C3)C)OC(C)CO.CS(=O)(=O)O
Molecular Formula
C22H28N4O9S2
CAS Number
1137916-97-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-0941 mesylate biochemical
MK-0941 mesylate (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065uM in 2.5 and 10 mM glucose, respectively; increases insulin secretion by 17-fold and glucose uptake up to 18-fold, respectively, in isolated rat islets of Langerhans and hepatocytes at 10uM; exhibits strong glucose-lowering activity in rodent models of type 2 diabetes and healthy dogs. Diabetes Phase 2 Discontinued
Product Categories/Family for MK-0941 mesylate biochemical
References
1. Eiki J, et al. Mol Pharmacol. 2011 Dec; 80 (6):1156-65.
2. Meininger GE, et al. Diabetes Care. 2011 Dec; 34 (12):2560-6.
2. Meininger GE, et al. Diabetes Care. 2011 Dec; 34 (12):2560-6.
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Product Notes
The MK-0941 mesylate (Catalog #AAA3600484) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-0941 mesylate, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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