Structure
NSC-59984 biochemical
NSC-59984
Purity
>=98% by HPLC
Synonyms
NSC-59984; (E)-1- (4-methylpiperazin-1-yl)-3- (5-nitrofuran-2-yl) prop-2-en-1-one; NSC-59984 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
Crystalline solid
Salt Form
No
Molecular Formula
C12H5N3O4
CAS Number
803647-40-7
Cell-Permeable
Yes
Reconstitution
DMSO
SMILES
CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]
InChi
InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+
InChi Key
QKTRIGNWBRHBFV-DUXPYHPUSA-N
Preparation and Storage
Store at -20 degree C for 36 months.
Protect from air and light.
Protect from air and light.
Structure
Structure
Related Product Information for NSC-59984 biochemical
NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC-59984 in most cancer cells is significantly lower than those of normal cells; with EC50 of 8.38 muM for p53-null HCT116 cells. NSC-59984 induces p73-dependent cell apoptosis in cancer in vivo.
Similar Products
Product Notes
The NSC-59984 (Catalog #AAA846199) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NSC-59984, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
