Structure
Necrostatin-1 Biochemical | Pcsk1 biochemical
Necrostatin-1
Gene Names
Pcsk1; PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1
Purity
>=98% by TLC
Synonyms
Necrostatin-1; 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; Nec-1; Pcsk1 biochemical
Purity/Purification
>=98% by TLC
Form/Format
Appearance: Yellow solid
Sequence Length
753
CAS Number
4311-88-0
Structure Available?
Yes
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD00056916
PubChem CID
2828334
Solubility/Reconstitution Instructions
DMSO (~25 mg/ml) or EtOH (~ 6 mg/ml)
SMILES
CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChi
InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChi Key
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Handling
Protect from air and light
Preparation and Storage
At -20 degree C
Shelf Life: 24 months
Shelf Life: 24 months
Structure
Structure
Related Product Information for Pcsk1 biochemical
Background: Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC?? = 180 nM).
Product Categories/Family for Pcsk1 biochemical
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
259.33
NCBI Official Full Name
neuroendocrine convertase 1
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 1
NCBI Official Symbol
Pcsk1
NCBI Official Synonym Symbols
PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1
NCBI Protein Information
neuroendocrine convertase 1
UniProt Protein Name
Neuroendocrine convertase 1
Protein Family
UniProt Gene Name
Pcsk1
UniProt Synonym Gene Names
Att-1; Nec-1; Nec1; NEC 1; PC1
UniProt Entry Name
NEC1_MOUSE
Uniprot Description
PCSK1: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily.
Protein type: Protease; EC 3.4.21.93
Cellular Component: Golgi apparatus; extracellular space; cytoplasmic vesicle
Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity
Biological Process: peptide hormone processing; protein processing; proteolysis; peptide biosynthetic process
Research Articles on Pcsk1
Similar Products
Product Notes
The Pcsk1 pcsk1 (Catalog #AAA842768) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Necrostatin-1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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