Structure
MK-8825 Biochemical
MK-8825
Purity
>98% (HPLC)
Synonyms
MK-8825; MK8825; MK-8825 biochemical
Purity/Purification
>98% (HPLC)
Target
CGRP Receptor
Receptor
CGRP Receptor
Chemical Name
2-[(8R)-8-(3, 5-difluorophenyl)-8-methyl-10-oxo-6, 9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1', 2', 5, 7-tetrahydrospiro[cyclopenta[b]pyridine-6, 3'-pyrrolo[2, 3-b]pyridin]-3-yl]acetamide
SMILES
CC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)N=C3)C7=CC(=CC(=C7)F)F
Molecular Formula
C31H30F2N6O3
CAS Number
1380887-60-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-8825 biochemical
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23nM; possesses significantly improved in vivo potency in rat pharmacodynamic models. Migraine Phase 1 Clinical
Product Categories/Family for MK-8825 biochemical
References
1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15; 22 (12):3941-5.
2. Michot B, et al. Eur J Pain. 2015 Feb; 19 (2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep; 271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20; 14:93.
2. Michot B, et al. Eur J Pain. 2015 Feb; 19 (2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep; 271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20; 14:93.
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Product Notes
The MK-8825 (Catalog #AAA3601576) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-8825, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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