Structure
MGL-3196 biochemical
MGL-3196
Purity
0.98
Synonyms
MGL-3196; Resmetirom; VIA-3196; 2-[3; 5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3; 5-dioxo-1; 2; 4-triazine-6-carbonitrile; 2-(3; 5-dichloro-4-((5-isopropyl-6-oxo-1; 6-dihydropyridazin-3-yl)oxy)phenyl)-3; 5-dioxo-2; 3; 4; 5-tetrahydro-1; 1; 4-Triazine-6-carbonitrile; 5-dichloro-4-{[6-hydroxy-5-(propan-2-yl)pyridazin-3-yl]oxy}phenyl)-5-hydroxy-3-oxo-2; 3-dihydro-1; MGL-3196 biochemical
Specificity
A selective thyroid hormone receptor beta agonist
Purity/Purification
0.98
Form/Format
Light yellow powder
Solubilities
~20mg/ml in DMSO and DMF; ~1mg/ml in Ethanol
Molecular Formula
C??H??Cl?N?O?
InChi
InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25-17(28)21-16(27)12(6-20)24-25/h3-5; 7H; 1-2H3; (H; 23; 26)(H; 21; 27; 28)
InChi Key
FDBYIYFVSAHJLY-UHFFFAOYSA-N
SMILES
CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
CAS Number
920509-32-6
MDL Number
MFCD26142653
PubChem CID
15981237
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36months
Country of Origin: USA
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36months
Country of Origin: USA
Structure
Structure
Related Product Information for MGL-3196 biochemical
A selective thyroid hormone receptor beta agonist with EC50 values of 0.21 and 3.74uM for THRbeta and THRalpha, respectively. It significantly lowers non-HDL-C and liver TG in hypercholesterolemic rat and rabbit models at doses where there is no effect on TSH levels or the central thyroid axis. It significantly decreased LDL-C by up to 30%, and showed a statistical trend to reduce TG up to 60% in healthy volunteers, at once daily oral dose of 50mg or higher for 2 weeks. It does not show THR-alpha mediated gene expression in a rat heart model indicating low potential for cardiac adverse effects. In vitro assays are predictive of lower off target actions. It shows an IC?? of ~30uM for blockage of the hERG channel and IC50 >50uM for CYP3A4/5 and CYP2C19. Formulations containingmgL-3196 are in clinical trials for the treatment of dyslipidemia.
Product Categories/Family for MGL-3196 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/15981237
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Product Notes
The MGL-3196 (Catalog #AAA8400451) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MGL-3196, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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