Cenicriviroc Biochemical

Cenicriviroc

Cat. Num. AAA8400467

• Purity: >=98%
• Synonyms: Cenicriviroc; TAK-652; TBR-652; (5E)-8-[4-(2-butoxyethoxy)phenyl]-1-(2-methylpropyl)-N-[4-[(S)-(3-propylimidazol-4-yl)methylsulfinyl]phenyl]-3; 4-dihydro-2H-1-benzazocine-5-carboxamide; (S; E)-8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1; 2; 3; 4-tetrahydrobenzo[b]azocine-5-carboxamide; Cenicriviroc biochemical

• Specificity: A potent inhibitor of CCR5 and CCR2
• Purity/Purification: >=98%
• Form/Format: Yellow Solid

• Solubilities: ~5mg/ml in ethanol; ~20mg/ml in DMSO and DMF
• Molecular Formula: C??H??N?O?S
• InChi: InChI=1S/C41H52N4O4S/c1-5-7-22-48-23-24-49-38-15-10-32(11-16-38)33-12-19-40-35(25-33)26-34(9-8-21-44(40)28-31(3)4)41(46)43-36-13-17-39(18-14-36)50(47)29-37-27-42-30-45(37)20-6-2/h10-19; 25-27; 30-31H; 5-9; 20-24; 28-29H2; 1-4H3; (H; 43; 46)/b34-26+/t50-/m0/s1
• InChi Key: PNDKCRDVVKJPKG-WHERJAGFSA-N
• SMILES: CCCCOCCOC1=CC=C(C=C1)C2=CC3=C(C=C2)N(CCCC(=C3)C(=O)NC4=CC=C(C=C4)S(=O)CC5=CN=CN5CCC)CC(C)C
• CAS Number: 497223-25-3
• MDL Number: MFCD28502076
• PubChem CID: 11285792
• Preparation and Storage: Store at -20 degree C; Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.; Shipping: Gel Pack; Shelf Life: Est.~36months; Country of Origin: USA

Structure

Related Product Information for Cenicriviroc biochemical

Cenicriviroc is a potent inhibitor of C-C chemokine receptors CCR5 and CCR2. It is an orally bioavailable derivative of TAK-779 with potent anti-HIV-1 activity. It blocks the binding of MIP-1alpha and MIP-1beta to CCR5 with an IC50 of 2.3nM. It inhibits the binding of MCP-1 to CCR2b with an IC50 of 5.9nM. It inhibits the replication of R5X4HIV-1 in U87.CD4.CCR5 cells at a concentration of 100nM. It shows potent anti-inflammatory and antifibrotic activity in animal models of fibrosis.

Product Categories/Family for Cenicriviroc biochemical

Web Categories; Biochemicals; Biochemicals (A-Z); Antiviral Agents

References

https://pubchem.ncbi.nlm.nih.gov/compound/11285792