Structure
Siponimod Biochemical
Siponimod (BAF-312)
Purity
>=98%
Synonyms
Siponimod; Siponimod (BAF-312); 1-[[4-[(E)-N-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-C-methylcarbonimidoyl]-2-ethylphenyl]methyl]azetidine-3-carboxylic acid; 3-Azetidinecarboxylic acid; 1-((4-((1E)-1-(((4-cyclohexyl-3-(trifluoromethyl)phenyl)methoxy)imino)ethyl)-2-ethylphenyl)methyl); 1-{4-[1-((E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl}-azetidine-3-carboxylic acid; Siponimod biochemical
Specificity
An agonist of the S1P1 and SIP5 receptors
Purity/Purification
>=98%
Form/Format
White to off-white solid powder
Solubilities
~16mg/ml in DMF; ~3mg/ml in ethanol; ~20mg/ml in DMSO
Molecular Formula
C??H??F?N?O?
InChi
InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30; 31)32/h9-14; 22; 25H; 3-8; 15-18H2; 1-2H3; (H; 35; 36)/b33-19+
InChi Key
KIHYPELVXPAIDH-HNSNBQBZSA-N
SMILES
CCC1=C(C=CC(=C1)C(=NOCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)C)CN4CC(C4)C(=O)O
CAS Number
1230487-00-9
MDL Number
MFCD26142651
PubChem CID
44599207
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shelf Life: Est.~36 months
Country of Origin: USA
Structure
Structure
Related Product Information for Siponimod biochemical
Siponimod is an orally bioavailable agonist of the sphingosine-1-phosphate (S1P) receptor that is selective for S1P1 and S1P5 with EC50 values of 0.39 and 0.98nM respectively, in a GTPgammaS-binding assay. Siponimod (0.3 or 3mg/kg/daymg/kg/day) reduces experimental autoimmune encephalomyelitis (EAE) symptoms in rats. It significantly attenuates demyelination in organotypic cerebellar slice cultures. It is used for the treatment of relapsing forms of multiple sclerosis.
Product Categories/Family for Siponimod biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/44599207
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Product Notes
The Siponimod (Catalog #AAA8400477) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Siponimod, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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