Structure
BAY 1024767 Biochemical
BAY 1024767
Purity
>98% (HPLC)
Synonyms
BAY 1024767; BAY1024767; BAY 1024767 biochemical
Purity/Purification
>98% (HPLC)
Target
Androgen Receptor (AR)
Receptor
Androgen Receptor (AR)
Chemical Name
4-(3-((6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl)methyl)-4, 4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
Molecular Formula
C23H23F3N4O3S
CAS Number
1273068-71-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BAY 1024767 biochemical
BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46nM) and mutant forms located in the AR ligand-binding domain (LBD); inhibits mutants L701H, E709Y, V715M, W741C, H874Y (IC50=31nM), F876L, T877A, M895T and M895V (IC50=11nM); promotes nuclear localization of AR wild-type and mutants in the absence of R1881 in COS-7 cells; demonstrates KuCaP-1 prostate cancer model which bears the W741C bicalutamide resistance mutation and in the syngeneic prostate cancer rat model Dunning R3327-G.
Product Categories/Family for BAY 1024767 biochemical
References
1. Sugawara T, et al. Oncotarget. 2016 Feb 2; 7 (5):6015-28.
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Product Notes
The BAY 1024767 (Catalog #AAA3601142) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BAY 1024767, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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