Structure
AC-186 Biochemical
AC-186
Purity
0.95
Synonyms
AC-186; 4-[4; 4-difluoro-1- (2-fluorophenyl) cyclohexyl]phenol; AC-186 biochemical
Purity/Purification
0.95
Form/Format
Solid
Solubility
~30 mg/ml in DMSO
Molecular Formula
C??H??F?O
CAS Number
1421854-16-1
PubChem CID
71245042
SMILES
C1CC (CCC1 (C2=CC=C (C=C2)O)C3=CC=CC=C3F)(F)F
InChi
InChI=1S/C18H17F3O/c19-16-4-2-1-3-15 (16)17 (9-11-18 (20,21)12-10-17)13-5-7-14 (22)8-6-13/h1-8,22H,9-12H2
InChi Key
HSMUKSLNDJOZQG-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Shelf life: ~36 months
Structure
Structure
Related Product Information for AC-186 biochemical
AC-186 is a potent and selective estrogen receptor beta (ERbeta) agonist. It shows EC50 values of 6 and 5000 nM for ERbeta and ERalpha respectively in functional assays. Decrease in the sex steroids is associated with increased risk of Alzheimer's disease. AC-186 exhibits gender selective neuroprotection in male animals in a rat model of Parkinson's disease. AC-186 in combination with ACP-105 increases the amyloid-beta degrading enzymes neprilysin and insulin-degrading enzyme, decreases amyloid-beta levels in the brain as well as improves cognition in a mouse model of Alzheimer's Disease.
Product Categories/Family for AC-186 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/71245042
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Product Notes
The AC-186 (Catalog #AAA849075) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AC-186, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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