Bcl-2-like protein 1 (Bcl2l1) Recombinant Protein | Bcl2l1 recombinant protein

Recombinant Rat Bcl-2-like protein 1 (Bcl2l1) , partial

• Gene Names: Bcl2l1; Bclx; Bcl2l; bcl-X; Bcl-xl
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Bcl-2-like protein 1 (Bcl2l1); Recombinant Rat Bcl-2-like protein 1 (Bcl2l1); partial; Bcl2l1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 232

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 75992930
• NCBI GeneID: 24888
• NCBI Accession #: NP_001028842.1
• NCBI GenBank Nucleotide #: NM_001033670.1
• UniProt Accession #: P53563; P70613; P70614; Q52KS0; Q62678; Q62836; Q64087; Q64128
• Molecular Weight: 25,865 Da
• NCBI Official Full Name: bcl-2-like protein 1 isoform 2
• NCBI Official Synonym Full Names: Bcl2-like 1
• NCBI Official Symbol: Bcl2l1
• NCBI Official Synonym Symbols: Bclx; Bcl2l; bcl-X; Bcl-xl
• NCBI Protein Information: bcl-2-like protein 1
• UniProt Protein Name: Bcl-2-like protein 1
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: Bcl2l1
• UniProt Synonym Gene Names: Bclx; Blc2l; Bcl2-L-1

NCBI Description

inhibits neuronal apoptosis; may provide neuroprotection against ischemic brian injury [RGD, Feb 2006]

Uniprot Description

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release ().