Rabbit B-cell leukemia/lymphoma 2 ELISA Kit | BCL-2 elisa kit
Rabbit B-cell leukemia/lymphoma 2 (BCL-2) ELISA Kit
Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate BCL2 in Rabbit serum, plasma. An antibody specific for BCL2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any BCL2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for BCL2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of BCL2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity
Biological Process: B cell differentiation; negative regulation of axon extension; negative regulation of collateral sprouting; negative regulation of protein homooligomerization; negative regulation of transcription from RNA polymerase II promoter; positive regulation of collateral sprouting; positive regulation of transcription from RNA polymerase II promoter; protein sumoylation; regulation of dendrite development; signal transduction; T cell differentiation; transcription from RNA polymerase II promoter
Research Articles on BCL-2
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Product Notes
The Rabbit BCL-2 bcl11a (Catalog #AAA285920) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA285920 ELISA Kit recognizes Rabbit BCL-2. It is sometimes possible for the material contained within the vial of "B-cell leukemia/lymphoma 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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