SDS_PAGE
(Coomassie blue staining non-reduced and reduced SDS_PAGE analysis.)
CHO Cells Ipilimumab Antibody
Ipilimumab
Purity
> 95%
Synonyms
Ipilimumab; BMS-734016; MDX-010; MDX-CTLA-4; CTLA4; CD152; anti-Ipilimumab antibody
Host
CHO Cells
Isotype
IgG1-kappa
Specificity
Specificty Target Names (Species): CTLA4/CD152 [Homo Sapiens]
Purity/Purification
> 95%
Form/Format
PBS buffer, pH 7.5
Concentration
2.27 mg/ml (varies by lot)
CAS Number
477202-00-9
Species
Human (Homo Sapiens)
Activity in Vitro
Ipilimumab (anti-CTLA-4), is a fully humanized IgG1k monoclonal antibody produced by recombinant DNA technology in a CHO mammalian cell expression system, binding with high affinity to the extracellular domain of human (and Cynomolgus monkey) CTLA-4, and acting as an inhibitor of its complex functions. This essentially results in T-cell activation and proliferation, and in lymphocyte infiltration leading to tumor cell death. However, the enhancement of T effector cell function, combined with the inhibition of CD4+ Treg and CD8+ suppressive cell types, are considered essential for mediating the full therapeutic effects of ipilimumab. Ipilimumab can improve ATC proliferation, enhance the BiAb-mediated tumor-specific cytotoxicity, and increase cytokine synthesis, while it attenuates Treg activity as shown by decreased level of IL-10 secretion and reduced Treg population. Ipilimumab and nivolumab treatments could collaboratively enhance effector and memory T cell responses without inappropriately activating naive T cells.
Preparation and Storage
Store at 4°C for 1-2 weeks
Store at -20°C for 12 months
Store at -80°C for long term storage.
Use a manual defrost freezer and avoid repeated freeze/thaw cycles.
Store at -20°C for 12 months
Store at -80°C for long term storage.
Use a manual defrost freezer and avoid repeated freeze/thaw cycles.
SDS_PAGE
(Coomassie blue staining non-reduced and reduced SDS_PAGE analysis.)
SDS_PAGE
(Coomassie blue staining non-reduced and reduced SDS_PAGE analysis.)
Testing Data (TD)
Testing Data (TD)
Related Product Information for anti-Ipilimumab antibody
Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule that competes with the stimulatory CD28 for binding to B7 on antigen presenting cells.3 CTLA-4 and CD28 are both presented on the surface of T-cells.3 Ipilimumab is a human IgG1 that binds CTLA-4, preventing the inhibition of T-cell mediated immune responses to tumors.
Product Categories/Family for anti-Ipilimumab antibody
Similar Products
Product Notes
The Ipilimumab (Catalog #AAA156153) is an Antibody produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ipilimumab, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
