FMO2 Antibody | anti-FMO2 antibody

FMO2 Antibody

Cat. Num. AAA8503397

• Gene Names: FMO2; FMO1B1
• Synonyms: FMO2; FMO2 Antibody; anti-FMO2 antibody

• Sequence Length: 535

NCBI and Uniprot Product Information

• NCBI GI #: 672228738
• NCBI GeneID: 2327
• NCBI Accession #: NP_001451.2
• NCBI GenBank Nucleotide #: NM_001460.4
• UniProt Accession #: Q99518; Q5EBX4; Q86U73; Q9BRX1
• Molecular Weight: 53,644 Da
• NCBI Official Full Name: dimethylaniline monooxygenase
• NCBI Official Synonym Full Names: flavin containing monooxygenase 2
• NCBI Official Symbol: FMO2
• NCBI Official Synonym Symbols: FMO1B1
• NCBI Protein Information: dimethylaniline monooxygenase [N-oxide-forming] 2
• UniProt Protein Name: Dimethylaniline monooxygenase [N-oxide-forming] 2
• Protein Family: Dimethylaniline monooxygenase
• UniProt Gene Name: FMO2
• UniProt Synonym Gene Names: FMO 2

NCBI Description

This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Uniprot Description

Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.