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Western Blot (WB)
(Western Blot analysis of HepG2 cells with Caveolin-1 Polyclonal Antibody.)
Vesicle Trafficking Antibody Kit
Vesicle Trafficking Antibody Sampler Kit
Applications
Western Blot
Synonyms
Vesicle Trafficking; Vesicle Trafficking Antibody Sampler Kit; Vesicle Trafficking antibody kit
Applicable Applications for Vesicle Trafficking antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with Caveolin-1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with Caveolin-1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of Hela cells with Phospho-Caveolin-1 (Tyr14) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of Hela cells with Phospho-Caveolin-1 (Tyr14) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of NIH/3T3 and hela cell using CLTC Polyclonal Antibody at dilution of 1:300)
Western Blot (WB)
(Western Blot analysis of NIH/3T3 and hela cell using CLTC Polyclonal Antibody at dilution of 1:300)
Western Blot (WB)
(Western Blot analysis of A549 cells with APPL1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of A549 cells with APPL1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of K562 cells with EEA1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of K562 cells with EEA1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of Hela cells with Rab 5A Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of Hela cells with Rab 5A Polyclonal Antibody.)
Related Product Information for Vesicle Trafficking antibody kit
Background: Vesicle trafficking is an integral cellular process and the associated proteins involved also play major roles in other signaling pathways. Caveolins are involved in diverse biological functions including vesicular trafficking, cholesterol homeostasis, cell adhesion, apoptosis, and are also indicated in neurodegenerative disease. It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7. Clathrin-coated vesicles provide for the intracellular transport of proteins following endocytosis and during multiple vesicle trafficking pathways. Vesicles form at specialized areas of the cell membrane where clathrin and associated proteins form clathrin-coated pits. Invagination of these cell membrane-associated pits internalizes proteins and forms an intracellular clathrin-coated vesicle. Clathrin is the most abundant protein in these vesicles and is present as a basic assembly unit called a triskelion. Each clathrin triskelion is composed of three clathrin heavy chains and three clathrin light chains. Clathrin heavy chain proteins are composed of several functional domains that associate with other vesicle proteins. The APPL1 multidomain adaptor protein is a BAR-domain protein family member that is involved in membrane trafficking within a number of signal transduction pathways. EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking. Syntaxin 6 is a ubiquitously expressed S25C family member of the SNARE proteins. Syntaxin 6 protein is localized to the trans-Golgi and within endosomes and regulates membrane trafficking by partnering with a variety of other SNARE proteins. It has two coiled-coil domains (CC1 and CC2) located in the amino-terminal region and a PDZ domain in the carboxy-terminal region. The CC2 domain and its adjacent linker region mediate the association of GOPC with the Golgi protein golgin-160 and the Q-SNARE protein syntaxin 6. The PDZ domain of GOPC interacts with the carboxy terminus of target proteins to mediate target protein vesicular trafficking and surface expression. Rab5 is a member of the Ras superfamily of small Rab GTPases. Rab5 is localized at the plasma membrane and early endosomes and functions as a key regulator of vesicular trafficking during early endocytosis.
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Product Notes
The Vesicle Trafficking (Catalog #AAA2549989) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Vesicle Trafficking can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Vesicle Trafficking for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Vesicle Trafficking, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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