<
Western Blot (WB)
(Western Blot analysis of 293 cells with FAS Polyclonal Antibody.)
Death Receptor Antibody Kit | hdr antibody kit
Death Receptor Antibody Sampler Kit
Gene Names
hdr; ZH-DR; zgc:103531
Applications
Western Blot
Synonyms
Death Receptor; Death Receptor Antibody Sampler Kit; hdr antibody kit
Sequence Length
357
Applicable Applications for hdr antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of 293 cells with FAS Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 293 cells with FAS Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of Human brain tissue using TNFR1 Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of Human brain tissue using TNFR1 Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of 3T3, K562 cells using TNF-R2 Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of 3T3, K562 cells using TNF-R2 Polyclonal Antibody at dilution of 1:1000.)
Western Blot (WB)
(Western Blot analysis of A549 cell using TNFRSF10B Polyclonal Antibody at dilution of 1:500)
Western Blot (WB)
(Western Blot analysis of A549 cell using TNFRSF10B Polyclonal Antibody at dilution of 1:500)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with DcR3 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of HepG2 cells with DcR3 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of Hela cells using FADD Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of Hela cells using FADD Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of K562 cells with TRADD Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of K562 cells with TRADD Polyclonal Antibody.)
Related Product Information for hdr antibody kit
Background: The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TRAIL. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC) resulting in activation of caspases. Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2, and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. The RIP (receptor-interacting protein) family of serine-threonine kinases (RIP, RIP2, RIP3, and RIP4) are important regulators of cellular stress that can trigger pro-survival and inflammatory responses through the activation of NF-kappaB as well as pro- apoptotic pathways. In addition to the kinase domain, RIP contains a death domain responsible for interaction with the death domain receptor Fas and for the recruitment to TNFR1 through interaction with TRADD. Overexpression of RIP induces both NF-kappaB activation and apoptosis. Caspase-8 dependent cleavage of the death domain on RIP can trigger the apoptotic activity of RIP. RIP-deficient cells show a failure in TNF- mediated NF-kappaB activation, making the cells more sensitive to apoptosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
40,662 Da
NCBI Official Full Name
death receptor
NCBI Official Synonym Full Names
hematopoietic death receptor
NCBI Official Symbol
hdr
NCBI Official Synonym Symbols
ZH-DR; zgc:103531
NCBI Protein Information
hematopoietic death receptor
UniProt Protein Name
Death receptor
UniProt Gene Name
hdr
Similar Products
Product Notes
The hdr hdr (Catalog #AAA2550083) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Death Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the hdr hdr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Death Receptor, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
