Western Blot (WB)
(Western Blot analysis of Mouse skeletal muscle tissue using PIM3 Polyclonal Antibody at dilution of 1:250)
Pim Kinase Antibody Kit | Pim antibody kit
Pim Kinase Antibody Sampler Kit
Applications
Western Blot
Synonyms
Pim Kinase; Pim Kinase Antibody Sampler Kit; Pim antibody kit
Applicable Applications for Pim antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of Mouse skeletal muscle tissue using PIM3 Polyclonal Antibody at dilution of 1:250)
Western Blot (WB)
(Western Blot analysis of Mouse skeletal muscle tissue using PIM3 Polyclonal Antibody at dilution of 1:250)
Western Blot (WB)
(Western Blot analysis of Jurkat cells with Bad Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of Jurkat cells with Bad Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 293 cells with Phospho-Bad (Ser112) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 293 cells with Phospho-Bad (Ser112) Polyclonal Antibody)
Related Product Information for Pim antibody kit
Background: Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases. Pim-1, a serine/threonine kinase highly expressed in hematopoietic cells, plays a critical role in the transduction of mitogenic signals and is rapidly induced by a variety of growth factors and cytokines. Pim-1 cooperates with c-Myc in lymphoid cell transformation and protects cells from growth factor withdrawal and genotoxic stress-induced apoptosis. Pim-1 also enhances the transcriptional activity of c-Myb through direct phosphorylation within the c-Myb DNA binding domain as well as phosphorylation of the transcriptional coactivator p100. Hypermutations of the Pim-1 gene are found in B-cell diffuse large cell lymphomas. Phosphorylation of Pim-1 at Tyr218 by Etk occurs following IL-6 stimulation and correlates with an increase in Pim-1 activity. Various Pim substrates have been identified; Bad is phosphorylated by both Pim-1 and Pim-2 at Ser112 and this phosphorylation reverses Bad-induced cell apoptosis.
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Product Notes
The Pim (Catalog #AAA2550000) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Pim Kinase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Pim for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pim Kinase, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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