GDP-Man: Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (Alg11) Recombinant Protein | Alg11 recombinant protein
Recombinant Mouse GDP-Man:Man (3)GlcNAc (2)-PP-Dol alpha-1,2-mannosyltransferase (Alg11)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
ALG11: Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain. Defects in ALG11 are the cause of congenital disorder of glycosylation type 1P (CDG1P). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein type: EC 2.4.1.131; Membrane protein, integral; Membrane protein, multi-pass; Transferase; Glycan Metabolism - N-glycan biosynthesis
Cellular Component: endoplasmic reticulum; integral to membrane; membrane
Molecular Function: glycolipid 2-alpha-mannosyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups
Research Articles on Alg11
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Product Notes
The Alg11 alg11 (Catalog #AAA7007678) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-492aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Alg11 alg11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAADTGSWCV YAVLRFFYSL FFPGLMICGV LCVYLVIGLW VIRWHLQRKK KSVSTSKNGK EQTVVAFFHP YCNAGGGGER VLWCALRALQ KKYPEAVYVV YTGDINVSGQ QILDGAFRRF NIKLAHPVQF VFLRKRYLVE DSRYPHFTLL GQSLGSILLG WEALMQRVPD VYIDSMGYAF TLPLFKYVGG CRVGSYVHYP TISTDMLSVV KNQNPGFNNA AFISRNALLS KAKLIYYYLF AFVYGLVGSC SDIVMVNSSW TLNHILSLWK VGHCTNIVYP PCDVQTFLDI PLHEKKVTPG HLLVSIGQFR PEKNHALQIK AFAKLLNEKA AELGHSLKLV LIGGCRNKDD EFRVNQLRSL SENLGVQENV EFKINISFDE LKNYLSEATI GLHTMWNEHF GIGVVECMAA GTVILAHNSG GPKLDIVIPH EGQITGFLAE SEEGYADSMA HILSLSAEER LQIRKNARAS ISRFSDQEFE VAFLCSMEKL LT. It is sometimes possible for the material contained within the vial of "GDP-Man: Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (Alg11), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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