Specific Activity
(The specific activity of WWP2 was determined to be 53 nmol/min/mg as per activity assay protocol.)
WWP2 active protein
WWP2, Active Full-length human recombinant protein expressed in Sf9 cells
Purity
>90%
Synonyms
WWP2; Active Full-length human recombinant protein expressed in Sf9 cells; WWP2 active protein
Purity/Purification
>90%
Form/Format
Recombinant proteins stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Concentration
0.2 ug/ul (varies by lot)
Specific Activity
53 nmol/min/mg
Preparation and Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Shipping: Ships with Dry Ice.
Stability: 1yr at -70°C from date of shipment
Shipping: Ships with Dry Ice.
Stability: 1yr at -70°C from date of shipment
Specific Activity
(The specific activity of WWP2 was determined to be 53 nmol/min/mg as per activity assay protocol.)
Specific Activity
(The specific activity of WWP2 was determined to be 53 nmol/min/mg as per activity assay protocol.)
Purity Data
(The purity of WWP2 was determined to be >90% by densitometry, approx. MW 130 kDa.)
Purity Data
(The purity of WWP2 was determined to be >90% by densitometry, approx. MW 130 kDa.)
Related Product Information for WWP2 active protein
Recombinant full-length human WWP2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The WWP2 gene accession number is NM_007014.
WWP2 or WW domain containing E3 ubiquitin protein ligase 2 is a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. WWP2 contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. WWP2 is an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. WWP2 which is also called AIP2 can bind to atrophin-1.
WWP2 or WW domain containing E3 ubiquitin protein ligase 2 is a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. WWP2 contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. WWP2 is an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. WWP2 which is also called AIP2 can bind to atrophin-1.
References
1. Xu, H.M. et al: Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J. Biol. Chem. 279: 23495-23503, 2004
2. Wood, J.D. et al: Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol. Cell. Neurosci. 11: 149-160, 1998
2. Wood, J.D. et al: Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol. Cell. Neurosci. 11: 149-160, 1998
NCBI and Uniprot Product Information
NCBI Accession #
NCBI GenBank Nucleotide #
Protein Family
Similar Products
Product Notes
The WWP2 (Catalog #AAA515710) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "WWP2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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