Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Tissue inhibitors of metalloproteinase 2 (TIMP2) Standard Curve.)
Mouse Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit | TIMP2 elisa kit
Mouse Tissue Inhibitors Of Metalloproteinase 2 (TIMP2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Tissue inhibitors of metalloproteinase 2 (TIMP2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Mouse Tissue inhibitors of metalloproteinase 2 (TIMP2) Standard Curve.)
Background: TIMP2, is a member of the TIMP family. The proteins are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF.
NCBI and Uniprot Product Information
Uniprot Description
TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.
Protein type: Inhibitor; Secreted, signal peptide; Secreted; Cell development/differentiation; Motility/polarity/chemotaxis; Extracellular matrix
Cellular Component: extracellular space; neuron projection; cell surface; growth cone; cell soma; extracellular region; basement membrane
Molecular Function: integrin binding; enzyme inhibitor activity; metalloendopeptidase inhibitor activity; protease binding; protease inhibitor activity; metal ion binding; enzyme activator activity
Biological Process: positive regulation of catalytic activity; negative regulation of proteolysis; regulation of Rap protein signal transduction; negative regulation of metalloenzyme activity; regulation of neuron differentiation; regulation of cAMP metabolic process; response to hormone stimulus; negative regulation of peptidase activity; negative regulation of membrane protein ectodomain proteolysis; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to cytokine stimulus; regulation of MAPKKK cascade; negative regulation of Ras protein signal transduction; negative regulation of mitotic cell cycle; positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation
Research Articles on TIMP2
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Product Notes
The Mouse TIMP2 timp2 (Catalog #AAA9718024) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9718024 ELISA Kit recognizes Mouse TIMP2. It is sometimes possible for the material contained within the vial of "Tissue Inhibitors Of Metalloproteinase 2 (TIMP2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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