Cyclin-dependent kinase 4 inhibitor B (Cdkn2b) Recombinant Protein | Cdkn2b recombinant protein
Recombinant Rat Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)
Gene Names
Cdkn2b; p15
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Cyclin-dependent kinase 4 inhibitor B (Cdkn2b); Recombinant Rat Cyclin-dependent kinase 4 inhibitor B (Cdkn2b); Cdkn2b recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-130, Full length protein
Sequence
MLGGGSDAGLATAAARGQVETVRQLLEAGADPNAVNRFGRRPIQVMMMGSAQVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLMVLHKAGARLDVCDAWGRLPVDLAEEQGHRDIARYLHAATGD
Sequence Length
130
Species
Rat
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Cdkn2b recombinant protein
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
9,174 Da
NCBI Official Full Name
cyclin-dependent kinase 4 inhibitor B
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 2B
NCBI Official Symbol
Cdkn2b
NCBI Official Synonym Symbols
p15
NCBI Protein Information
cyclin-dependent kinase 4 inhibitor B
UniProt Protein Name
Cyclin-dependent kinase 4 inhibitor B
Protein Family
UniProt Gene Name
Cdkn2b
UniProt Synonym Gene Names
Ink4
NCBI Description
may play a role as tumor suppressor; mutations may cause renal carcinoma (RC) in Eker rat [RGD, Feb 2006]
Uniprot Description
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest ().
Research Articles on Cdkn2b
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Product Notes
The Cdkn2b cdkn2b (Catalog #AAA966155) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-130, Full length protein. The amino acid sequence is listed below: MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI ARYLHAATGD. It is sometimes possible for the material contained within the vial of "Cyclin-dependent kinase 4 inhibitor B (Cdkn2b), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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