Rabbit KYAT3 Polyclonal Antibody | anti-KYAT3 antibody

KYAT3 Antibody

Cat. Num. AAA9630937

• Gene Names: CCBL2; KAT3; KATIII
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: KYAT3; Polyclonal Antibody; KYAT3 Antibody; CCBL 2; Cysteine conjugate beta lyase 2; Cysteine S conjugate beta lyase 2; DKFZp547N1117; DKFZp667D0223; KAT 3; KAT III; KAT3; KATIII; Kynurenine aminotransferase III; Kynurenine oxoglutarate transaminase 3; Kynurenine oxoglutarate transaminase III; MGC9398; RBM1; RBMX L1; RBMXL 1; RBMXL1; RNA binding motif protein X linked like 1; RP11 82K18.3; RP4 531M19.2; anti-KYAT3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: KYAT3 Antibody detects endogenous levels of KYAT3.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-KYAT3 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human KYAT3.
• Conjugation: Unconjugated
• Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
• Subunit Structure: Homodimer.
• Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-KYAT3 antibody

Primary

NCBI and Uniprot Product Information

• NCBI GI #: 56713256
• NCBI GeneID: 56267
• NCBI Accession #: NP_001008662.1
• NCBI GenBank Nucleotide #: NM_001008662.2
• UniProt Accession #: Q6YP21; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q9BVY5; B3KQ13
• Molecular Weight: 51,400 Da
• NCBI Official Full Name: kynurenine--oxoglutarate transaminase 3 isoform 2
• NCBI Official Synonym Full Names: cysteine conjugate-beta lyase 2
• NCBI Official Symbol: CCBL2
• NCBI Official Synonym Symbols: KAT3; KATIII
• NCBI Protein Information: kynurenine--oxoglutarate transaminase 3; RP11-82K18.3; kynurenine aminotransferase III; cysteine-S-conjugate beta-lyase 2; kynurenine--glyoxylate transaminase; kynurenine-oxoglutarate transaminase 3; kynurenine--oxoglutarate transaminase III
• UniProt Protein Name: Kynurenine--oxoglutarate transaminase 3
• Protein Family: Kynurenine--oxoglutarate transaminase
• UniProt Gene Name: CCBL2
• UniProt Synonym Gene Names: KAT3; KATIII
• UniProt Entry Name: KAT3_HUMAN

NCBI Description

This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid. Kynurenic acid is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Jun 2009]

Uniprot Description

CCBL2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lyase; EC 2.6.1.63; EC 2.6.1.7; Transferase; EC 4.4.1.13

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: mitochondrion

Molecular Function: cysteine-S-conjugate beta-lyase activity; protein homodimerization activity; kynurenine-oxoglutarate transaminase activity; kynurenine-glyoxylate transaminase activity; pyridoxal phosphate binding

Biological Process: amino acid metabolic process; biosynthetic process; tryptophan catabolic process; 2-oxoglutarate metabolic process