LGALS3BP blocking peptide

LGALS3BP Blocking Peptide

Cat. Num. AAA9620784

• Gene Names: LGALS3BP; 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: LGALS3BP; LGALS3BP Blocking Peptide; 90K; 90K MAC 2 BP; Basement membrane autoantigen p105; BTBD17B; Galectin 3 binding protein; Galectin-3-binding protein; L3 antigen; Lectin galactoside binding soluble 3 binding protein; Lectin galactoside-binding soluble 3-binding protein; LG3BP_HUMAN; M2BP; Mac 2 binding protein; Mac 2 BP; Mac-2 BP; Mac-2-binding protein; Mac2 BP; MAC2BP; Serum protein 90K; TANGO10B; Transport and golgi organization 10 homolog B; Tumor associated antigen 90K; Tumor-associated antigen 90K; LGALS3BP blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for LGALS3BP blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LGALS3BP blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 5031863
• NCBI GeneID: 3959
• NCBI Accession #: NP_005558.1
• NCBI GenBank Nucleotide #: NM_005567.3
• UniProt Accession #: Q08380; Q7M4S0; Q9UCH8; Q9UCH9; Q9UCI0
• Molecular Weight: 65,331 Da
• NCBI Official Full Name: galectin-3-binding protein
• NCBI Official Synonym Full Names: galectin 3 binding protein
• NCBI Official Symbol: LGALS3BP
• NCBI Official Synonym Symbols: 90K; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B
• NCBI Protein Information: galectin-3-binding protein
• UniProt Protein Name: Galectin-3-binding protein
• Protein Family: Galectin-3-binding protein
• UniProt Gene Name: LGALS3BP
• UniProt Synonym Gene Names: M2BP; MAC2BP; Mac-2 BP
• UniProt Entry Name: LG3BP_HUMAN

NCBI Description

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]

Uniprot Description

LGALS3BP: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: extracellular matrix; extracellular region; extracellular space; membrane; proteinaceous extracellular matrix

Molecular Function: scavenger receptor activity

Biological Process: cell adhesion; cellular defense response; platelet degranulation; receptor-mediated endocytosis; signal transduction