Leukosialin (Spn) Recombinant Protein | Spn recombinant protein
Recombinant Mouse Leukosialin (Spn)
NCBI and Uniprot Product Information
Uniprot Description
sialophorin: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX. Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Protein type: Membrane protein, integral; Cell surface
Cellular Component: extracellular space; microvillus; cell surface; membrane; integral to plasma membrane; integral to membrane; basement membrane; uropod; external side of plasma membrane; cleavage furrow
Molecular Function: protein domain specific binding; protein binding
Biological Process: positive regulation of tumor necrosis factor biosynthetic process; regulation of immune response; regulation of defense response to virus; negative regulation of cell adhesion; negative thymic T cell selection; negative regulation of T cell proliferation; response to protozoan; cell surface receptor linked signal transduction; T cell costimulation; defense response to bacterium; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; negative regulation of type IV hypersensitivity; negative regulation of T cell activation
Research Articles on Spn
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Product Notes
The Spn spn (Catalog #AAA955599) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 20-248. The amino acid sequence is listed below: D SLQRTTMLPS TPHITAPSTS EAQNASPSVS VGSGTVDSKE TISPWGQTTI PVSLTPLETT ELSSLETSAG ASMSTPVPEP TASQEVSSKT SALLPEPSNV ASDPPVTAAN PVTDGPAANP VTDGTAASTS ISKGTSAPPT TVTTSSNETS GPSVATTVSS KTSGPPVTTA TGSLGPSSEM HGLPATTATS SVESSSVARG TSVSSRKTST TSTQDPITTR SPSQESSG. It is sometimes possible for the material contained within the vial of "Leukosialin (Spn), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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