Mouse Leukosialin ELISA Kit | Spn elisa kit

Mouse Leukosialin ELISA Kit

Cat. Num. AAA2884393

• Gene Names: Spn; Cd43; Ly48; Galgp; Ly-48; A630014B01Rik
• Reactivity: Mouse
• Synonyms: Leukosialin; Mouse Leukosialin ELISA Kit; B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48; Ly-48; Sialophorin; Spn; CD43; Spn elisa kit

• Reactivity: Mouse
• Sequence Length: 395

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.159 ng/mL
• Intra-Assay CV: <=5.9%
• Inter-Assay CV: <=10.5%
• Recovery: 102%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 83716013
• NCBI GeneID: 20737
• NCBI Accession #: NP_001032899.1
• NCBI GenBank Nucleotide #: NM_001037810.2
• UniProt Accession #: P15702
• Molecular Weight: 40,038 Da
• NCBI Official Full Name: leukosialin
• NCBI Official Synonym Full Names: sialophorin
• NCBI Official Symbol: Spn
• NCBI Official Synonym Symbols: Cd43; Ly48; Galgp; Ly-48; A630014B01Rik
• NCBI Protein Information: leukosialin
• UniProt Protein Name: Leukosialin
• Protein Family: Leukosialin
• UniProt Gene Name: Spn
• UniProt Synonym Gene Names: Ly-48
• UniProt Entry Name: LEUK_MOUSE

Uniprot Description

sialophorin: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX. Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: basement membrane; cell surface; cleavage furrow; external side of plasma membrane; extracellular space; integral to membrane; integral to plasma membrane; membrane; microvillus; uropod

Molecular Function: protein binding; protein domain specific binding

Biological Process: cell surface receptor linked signal transduction; defense response to bacterium; negative regulation of cell adhesion; negative regulation of T cell activation; negative regulation of T cell proliferation; negative regulation of type IV hypersensitivity; negative thymic T cell selection; positive regulation of protein amino acid phosphorylation; positive regulation of T cell proliferation; positive regulation of tumor necrosis factor biosynthetic process; regulation of defense response to virus; regulation of immune response; response to protozoan; T cell costimulation