Testing Data
(The TFact FOXC1/2 DNA-Binding ELISA detects active FOXC1/2 in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by serum (20% FBS) before harvest.)
FOXC1/2 elisa kit
FOXC1/2 TFact DNA-Binding ELISA Kit
Testing Data
(The TFact FOXC1/2 DNA-Binding ELISA detects active FOXC1/2 in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by serum (20% FBS) before harvest.)
Testing Data
(The TFact FOXC1/2 DNA-Binding ELISA detects active FOXC1/2 in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by serum (20% FBS) before harvest.)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
Uniprot Description
FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p25.3
Cellular Component: cytosol; nuclear heterochromatin; nucleoplasm; nucleus
Molecular Function: DNA binding; DNA binding transcription factor activity; DNA binding, bending; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding
Biological Process: artery morphogenesis; blood vessel remodeling; camera-type eye development; cardiac muscle cell proliferation; cell migration; cell proliferation; cerebellum development; collagen fibril organization; embryonic heart tube development; endochondral ossification; eye development; germ cell migration; glycosaminoglycan metabolic process; heart development; in utero embryonic development; kidney development; lacrimal gland development; lymph vessel development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; Notch signaling pathway; odontogenesis of dentine-containing teeth; ovarian follicle development; paraxial mesoderm formation; positive regulation of DNA binding; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of blood vessel size; regulation of organ growth; regulation of transcription, DNA-templated; somitogenesis; transcription from RNA polymerase II promoter; ureteric bud development; vascular endothelial growth factor receptor signaling pathway; ventricular cardiac muscle tissue morphogenesis
Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
Research Articles on FOXC1/2
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Product Notes
The Human, Mouse, Rat FOXC1/2 foxc1 (Catalog #AAA9502173) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502173 ELISA Kit recognizes Human, Mouse, Rat FOXC1/2. It is sometimes possible for the material contained within the vial of "FOXC1/2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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