Mouse anti-Human, Mouse KHDRBS2 Monoclonal Antibody | anti-KHDRBS2 antibody

KHDRBS2 Antibody

Cat. Num. AAA9435255

• Gene Names: KHDRBS2; SLM1; SLM-1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: ProA affinity purified
• Synonyms: KHDRBS2; Monoclonal Antibody; KHDRBS2 Antibody; KH domain containing; RNA binding; signal transduction associated protein 2 antibody; 6330586C16Rik antibody; bA535F17.1 antibody; FLJ38664 antibody; hSLM 1 antibody; hSLM-1 antibody; signal transduction associated 2 antibody; KH domain-containing antibody; KHDR2_HUMAN antibody; khdrbs2 antibody; MGC26664 antibody; RNA-binding antibody; Sam68 like mammalian protein 1 antibody; Sam68-like mammalian protein 1 antibody; signal transduction-associated protein 2 antibody; SLM 1 antibody; SLM-1 antibody; SLM1 antibody; anti-KHDRBS2 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Clone Number: C10-G8
• Purity/Purification: ProA affinity purified
• Form/Format: 1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Applicable Applications for anti-KHDRBS2 antibody: Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; FC/FACS: 1:50-1:100
• Immunogen: Recombinant protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C.

Western Blot (WB)

(Western blot analysis of KHDRBS2 on human KHDRBS2 recombinant protein using anti-KHDRBS2 antibody at 1/1, 000 dilution.)

Western Blot (WB)

(Western blot analysis of KHDRBS2 on different cell lysate using anti-KHDRBS2 antibody at 1/1, 000 dilution. Positive control�� Line1: K562 Line2: HEK293 Line3: NTERA-2 Line4: Hela Line5: HepG2 Line6: Jurkat Line7: A431 Line8: NIH/3T3)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-KHDRBS2 antibody. Counter stained with hematoxylin.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-KHDRBS2 antibody. Counter stained with hematoxylin.)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of K562 cells with KHDRBS2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).)

Related Product Information for anti-KHDRBS2 antibody

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly (A) and poly (U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.

Product Categories/Family for anti-KHDRBS2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 189217895
• NCBI GeneID: 202559
• NCBI Accession #: NP_689901.2
• NCBI GenBank Nucleotide #: NM_152688.3
• UniProt Accession #: Q5VWX1; Q8N4I4; Q8TCZ4; A8K7M8
• Molecular Weight: 39
• NCBI Official Full Name: KH domain-containing, RNA-binding, signal transduction-associated protein 2
• NCBI Official Synonym Full Names: KH RNA binding domain containing, signal transduction associated 2
• NCBI Official Symbol: KHDRBS2
• NCBI Official Synonym Symbols: SLM1; SLM-1
• NCBI Protein Information: KH domain-containing, RNA-binding, signal transduction-associated protein 2
• UniProt Protein Name: KH domain-containing, RNA-binding, signal transduction-associated protein 2
• Protein Family: KH domain-containing, RNA-binding, signal transduction-associated protein
• UniProt Gene Name: KHDRBS2
• UniProt Synonym Gene Names: SLM1; SLM-1; hSLM-1

Uniprot Description

KHDRBS2: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Belongs to the KHDRBS family.

Chromosomal Location of Human Ortholog: 6q11.1

Cellular Component: nucleoplasm

Molecular Function: identical protein binding; protein binding