Rabbit anti-Human CLASP2 Polyclonal Antibody | anti-CLASP2 antibody

CLASP2 Antibody

Cat. Num. AAA9429657

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CLASP2; Polyclonal Antibody; CLASP2 Antibody; anti-CLASP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total CLASP2 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 0.6mg/ml (varies by lot)
• Sequence Length: 1583

• Applicable Applications for anti-CLASP2 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1: 25-100
• Immunogen: Synthetic protein corresponding to residues near the C terminal of human CLASP2
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46510(CLASP2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200))

Related Product Information for anti-CLASP2 antibody

CLASP2 (cytoplasmic linker associated protein 2), also known as KIAA0627 or hOrbit2, is a 1, 294 amino acid protein that contains five HEAT repeats and localizes to the cytoplasm and the cytoskeleton, as well as to the kinetochore and the golgi apparatus. Expressed primarily in brain tissue, CLASP2 functions as a microtubule plus-end tracking protein that regulates the stability of dynamic microtubules and is required for the proper polarization of cytoplasmic microtubule arrays in migrating cells. CLASP2 interacts with EB1, EB3, ELKS and CLIP-115 and, in addition to stabilizing microtubules, plays an important role in maintaining the stability of the kinetochore and is crucial for proper chromosomal alignment. CLASP2 is subject to phosphorylation by GSK-3β, an event that is thought to negatively regulate the ability of CLASP2 to bind to microtubules. Two isoforms of CLASP2, designated beta and gamma, exist due to alternative splicing events.

Product Categories/Family for anti-CLASP2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 20810064
• NCBI GeneID: 23122
• UniProt Accession #: O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2; B2RTR1; F5H604
• Molecular Weight: 165,924 Da
• NCBI Official Full Name: Homo sapiens cytoplasmic linker associated protein 2, mRNA
• NCBI Official Synonym Full Names: cytoplasmic linker associated protein 2
• NCBI Official Symbol: CLASP2
• NCBI Protein Information: CLIP-associating protein 2
• UniProt Protein Name: CLIP-associating protein 2
• Protein Family: CLIP-associating protein
• UniProt Gene Name: CLASP2
• UniProt Synonym Gene Names: KIAA0627; hOrbit2

Uniprot Description

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.