Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 Recombinant Protein | PTPM1 recombinant protein

Recombinant Human Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Cat. Num. AAA9421265

• Gene Names: PTPMT1; MOSP; PLIP; DUSP23; PNAS-129
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Recombinant Human Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; PTEN-like phosphatasePhosphoinositide lipid phosphataseProtein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16; EC:3.1.3.48); PTPM1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 28-201aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for PTPM1 recombinant protein

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the mbrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells.

NCBI and Uniprot Product Information

• NCBI GI #: 221218988
• NCBI GeneID: 114971
• NCBI Accession #: NP_001137456.1
• NCBI GenBank Nucleotide #: NM_001143984.1
• UniProt Accession #: Q8WUK0; Q7Z557; Q96CR2; Q9BXV8; E9PAT8
• Molecular Weight: 35.9kD
• NCBI Official Full Name: phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, mitochondrial 1
• NCBI Official Symbol: PTPMT1
• NCBI Official Synonym Symbols: MOSP; PLIP; DUSP23; PNAS-129
• NCBI Protein Information: phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
• UniProt Protein Name: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
• Protein Family: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase
• UniProt Gene Name: PTPMT1
• UniProt Synonym Gene Names: MOSP; PLIP

Uniprot Description

PTPMT1: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.16; EC 3.1.3.27; EC 3.1.3.48; Mitochondrial; Phosphatase, lipid; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: mitochondrion; nucleus

Molecular Function: phosphatidylglycerophosphatase activity; phosphoinositide 5-phosphatase activity; protein binding

Biological Process: cardiolipin biosynthetic process