Rabbit anti-Human INSL3 Polyclonal Antibody | anti-INSL3 antibody

INSL3 Polyclonal Antibody

Cat. Num. AAA9419778

• Gene Names: INSL3; RLF; RLNL; ley-I-L
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
• Synonyms: INSL3; Polyclonal Antibody; INSL3 Polyclonal Antibody; Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]; anti-INSL3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous INSL3
• Purity/Purification: Affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
• Form/Format: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
• Concentration: 1 mg/ml (varies by lot)

• Applicable Applications for anti-INSL3 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-300
• Immunogen: Synthetic peptide from human protein at AA range: 10-50
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human-testis, antibody was diluted at 1:200)

Product Categories/Family for anti-INSL3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 388240756
• NCBI GeneID: 3640
• NCBI Accession #: NP_001252516.1
• NCBI GenBank Nucleotide #: NM_001265587.1
• UniProt Accession #: P51460; Q3KPI5; Q3KPI6; Q6YNB5; Q9UEA2; Q9UPH6; B4DZ72; G3XAG0
• Molecular Weight: 16,872 Da
• NCBI Official Full Name: insulin-like 3 isoform 1
• NCBI Official Synonym Full Names: insulin like 3
• NCBI Official Symbol: INSL3
• NCBI Official Synonym Symbols: RLF; RLNL; ley-I-L
• NCBI Protein Information: insulin-like 3
• UniProt Protein Name: Insulin-like 3
• Protein Family: Insulin
• UniProt Gene Name: INSL3
• UniProt Synonym Gene Names: RLF; RLNL; Ley-I-L

NCBI Description

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Uniprot Description

INSL3: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO); also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low. Belongs to the insulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular region

Molecular Function: insulin receptor binding; protease binding; receptor binding

Biological Process: cell-cell signaling; spermatogenesis

Disease: Cryptorchidism, Unilateral Or Bilateral