Rabbit anti-Human INSL3 Polyclonal Antibody | anti-INSL3 antibody

INSL3 Rabbit Polyclonal

Cat. Num. AAA7600568

• Gene Names: INSL3; RLF; RLNL; ley-I-L
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: INSL3; Polyclonal Antibody; INSL3 Rabbit Polyclonal; anti-INSL3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 157

• Applicable Applications for anti-INSL3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Insulin-like 3 (Leydig cell)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate using MBS7600568 (INSL3 antibody) at dilution of 1:50)

Western Blot (WB)

(A549 cells were subjected to SDS PAGE followed by western blot with MBS7600568 (INSL3 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 388240756
• NCBI GeneID: 3640
• NCBI Accession #: NP_001252516.1
• NCBI GenBank Nucleotide #: NM_001265587.1
• Molecular Weight: 16,872 Da
• NCBI Official Full Name: insulin-like 3 isoform 1
• NCBI Official Synonym Full Names: insulin like 3
• NCBI Official Symbol: INSL3
• NCBI Official Synonym Symbols: RLF; RLNL; ley-I-L
• NCBI Protein Information: insulin-like 3
• UniProt Protein Name: Insulin-like 3
• Protein Family: Insulin
• UniProt Gene Name: INSL3
• UniProt Synonym Gene Names: RLF; RLNL; Ley-I-L
• UniProt Entry Name: INSL3_HUMAN

NCBI Description

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Uniprot Description

INSL3: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO); also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low. Belongs to the insulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19p13.2-p12

Cellular Component: extracellular region; extracellular space; perinuclear region of cytoplasm

Molecular Function: G-protein-coupled receptor binding; hormone activity; insulin receptor binding; protease binding; receptor binding

Biological Process: cell-cell signaling; G-protein signaling, adenylate cyclase inhibiting pathway; male gonad development; negative regulation of apoptosis; negative regulation of cell proliferation; oocyte maturation; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; spermatogenesis

Disease: Cryptorchidism, Unilateral Or Bilateral