Western Blot (WB)
(Western blot analysis of Akirin2 in mouse brain tissue lysate with Akirin2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Rabbit anti-Human, Mouse Akirin2 Polyclonal Antibody | anti-AKIRIN2 antibody
Akirin2 Antibody
Gene Names
AKIRIN2; FBI1; C6orf166; dJ486L4.2
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
Akirin2; Polyclonal Antibody; Akirin2 Antibody; Chromosome 6 Open Reading Frame 166; C6orf166; FBI1; anti-AKIRIN2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
203
Applicable Applications for anti-AKIRIN2 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 15 amino acid peptide near the center of the human Akirin2.
Target Name
Akirin2
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of Akirin2 in mouse brain tissue lysate with Akirin2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of Akirin2 in mouse brain tissue lysate with Akirin2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.)
Related Product Information for anti-AKIRIN2 antibody
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Product Categories/Family for anti-AKIRIN2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
22,496 Da
NCBI Official Full Name
chromosome 6 open reading frame 166
NCBI Official Synonym Full Names
akirin 2
NCBI Official Symbol
AKIRIN2
NCBI Official Synonym Symbols
FBI1; C6orf166; dJ486L4.2
NCBI Protein Information
akirin-2
UniProt Protein Name
Akirin-2
Protein Family
UniProt Gene Name
AKIRIN2
UniProt Synonym Gene Names
C6orf166
UniProt Entry Name
AKIR2_HUMAN
Uniprot Description
AKIRIN2: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1. Belongs to the akirin family.
Protein type: Cell cycle regulation; Transcription regulation
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: transcriptional repressor complex; nucleus
Molecular Function: enzyme binding
Biological Process: embryonic development; transcription, DNA-dependent; positive regulation of cell proliferation; innate immune response; positive regulation of interleukin-6 production; response to lipopolysaccharide; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
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Product Notes
The AKIRIN2 akirin2 (Catalog #AAA9412544) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Akirin2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Akirin2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the AKIRIN2 akirin2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Akirin2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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