Rabbit anti-Human ALX4 Polyclonal Antibody | anti-ALX4 antibody

ALX4 Antibody

Cat. Num. AAA9403442

• Gene Names: ALX4; CRS5; FND2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Synonyms: ALX4; Polyclonal Antibody; ALX4 Antibody; ALX homeobox 4; FND2; anti-ALX4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total ALX4 protein.
• Form/Format: Supplied at 0.4mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
• Sequence Length: 411

• Applicable Applications for anti-ALX4 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:1000-1:5000; Western blotting: 1:500-1:1000
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from 27-45 amino acids of Human ALX homeobox 4
• Target Name: ALX4
• Preparation and Storage: Store at -20 degree C/1 year

Testing Data

(Gel: 10%SDS-PAGELane1: Human brain malignant glioma tissue lysate Lane2: Human liver cancer tissue lysateLysates: 30ug per lanePrimary antibody: 1/170 dilutionSecondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilutionExposure time: 2 minutes)

Related Product Information for anti-ALX4 antibody

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.

Product Categories/Family for anti-ALX4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 55743092
• NCBI GeneID: 60529
• NCBI Accession #: NP_068745
• NCBI GenBank Nucleotide #: NM_021926.3
• Molecular Weight: 44,241 Da
• NCBI Official Full Name: homeobox protein aristaless-like 4
• NCBI Official Synonym Full Names: ALX homeobox 4
• NCBI Official Symbol: ALX4
• NCBI Official Synonym Symbols: CRS5; FND2
• NCBI Protein Information: homeobox protein aristaless-like 4
• UniProt Protein Name: Homeobox protein aristaless-like 4
• Protein Family: Homeobox protein
• UniProt Gene Name: ALX4
• UniProt Synonym Gene Names: KIAA1788
• UniProt Entry Name: ALX4_HUMAN

NCBI Description

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009]

Uniprot Description

ALX4: Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development. Defects in ALX4 are the cause of parietal foramina 2 (PFM2); also known as foramina parietalia permagna (FPP). PFM2 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. PFM2 is also a clinical feature of Potocki- Shaffer syndrome. Defects in ALX4 are the cause of frontonasal dysplasia type 2 (FND2). The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Defects in ALX4 are a cause of Potocki-Shaffer syndrome (POSHS). A contiguous gene syndrome caused by deletion of the 11p11.2 region. Belongs to the paired homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleus; transcription factor complex

Molecular Function: DNA binding; protein heterodimerization activity

Biological Process: anterior/posterior pattern formation; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic skeletal morphogenesis; gut development; hair follicle development; muscle development; palate development; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; regulation of apoptosis; skeletal development; transcription from RNA polymerase II promoter

Disease: Craniosynostosis 5, Susceptibility To; Frontonasal Dysplasia 2; Parietal Foramina 2