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Western Blot (WB) (Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 ug/mL.)

Rabbit TREX2 Polyclonal Antibody | anti-TREX2 antibody

TREX2 Antibody

Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
TREX2; Polyclonal Antibody; TREX2 Antibody; Three prime repair exonuclease 2; anti-TREX2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
This TREX2 antibody will not cross-react with the related protein TREX1.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
236
Applicable Applications for anti-TREX2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a 15 amino acid peptide near the carboxy terminus of human TREX2.
Target Name
TREX2
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 ug/mL.)

Western Blot (WB) (Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of TREX2 in human liver tissue with TREX2 antibody at 2.5 ug/mL.)

Immunohistochemistry (IHC) (Immunohistochemistry of TREX2 in human liver tissue with TREX2 antibody at 2.5 ug/mL.)
Related Product Information for anti-TREX2 antibody
TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
Product Categories/Family for anti-TREX2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
25,922 Da
NCBI Official Full Name
three prime repair exonuclease 2
NCBI Official Synonym Full Names
three prime repair exonuclease 2
NCBI Official Symbol
TREX2
NCBI Protein Information
three prime repair exonuclease 2
UniProt Protein Name
Three prime repair exonuclease 2
UniProt Gene Name
TREX2
UniProt Entry Name
TREX2_HUMAN

NCBI Description

This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

Uniprot Description

TREX2: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. Belongs to the exonuclease superfamily. TREX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; EC 3.1.11.2; Deoxyribonuclease

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: nucleus

Molecular Function: protein homodimerization activity; nucleic acid binding; exodeoxyribonuclease III activity; 3'-5'-exodeoxyribonuclease activity; magnesium ion binding

Biological Process: DNA repair; DNA catabolic process, exonucleolytic; DNA metabolic process

Research Articles on TREX2

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Product Notes

The TREX2 trex2 (Catalog #AAA9403123) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TREX2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TREX2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the TREX2 trex2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TREX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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