Western Blot (WB)
(Western blot analysis of GEMC1 in mouse heart tissue lysate with GEMC1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide)
Rabbit anti-Human, Mouse GEMC1 Polyclonal Antibody | anti-GEMC1 antibody
GEMC1 Antibody
Gene Names
GMNC; GEMC1
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
GEMC1; Polyclonal Antibody; GEMC1 Antibody; Geminin coiled-coil domain-containing protein 1; anti-GEMC1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
334
Applicable Applications for anti-GEMC1 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide near the center of human GEMC1.
Target Name
GEMC1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of GEMC1 in mouse heart tissue lysate with GEMC1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide)
Western Blot (WB)
(Western blot analysis of GEMC1 in mouse heart tissue lysate with GEMC1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide)
Related Product Information for anti-GEMC1 antibody
The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.
Product Categories/Family for anti-GEMC1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
37,887 Da
NCBI Official Full Name
geminin coiled-coil domain-containing protein 1
NCBI Official Synonym Full Names
geminin coiled-coil domain containing
NCBI Official Symbol
GMNC
NCBI Official Synonym Symbols
GEMC1
NCBI Protein Information
geminin coiled-coil domain-containing protein 1
UniProt Protein Name
Geminin coiled-coil domain-containing protein 1
UniProt Gene Name
GMNC
UniProt Synonym Gene Names
GEMC1
UniProt Entry Name
GEMC1_HUMAN
Uniprot Description
GMNC: Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2- dependent recruitment of CDC45L onto replication origins. Belongs to the GEMC1 family.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: nucleus
Molecular Function: chromatin binding
Biological Process: cell proliferation; DNA replication initiation; cell cycle
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Product Notes
The GEMC1 gmnc (Catalog #AAA9401427) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GEMC1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GEMC1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the GEMC1 gmnc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GEMC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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