Mouse disrupted in schizophrenia 1 ELISA Kit | DISC1 elisa kit
Mouse Disrupted in schizophrenia 1 protein, DISC1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DISC1: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell development/differentiation
Cellular Component: microtubule; centrosome; mitochondrion; endoplasmic reticulum; dynein complex; postsynaptic membrane; kinesin complex; cytoskeleton; membrane; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; synapse; nucleus; cell junction
Molecular Function: protein binding; kinesin binding; protein complex binding
Biological Process: nervous system development; positive regulation of neuroblast proliferation; mitochondrial calcium ion homeostasis; Wnt receptor signaling pathway; TOR signaling pathway; cell proliferation in forebrain; pyramidal neuron migration; multicellular organismal development; positive regulation of axon extension; neuron migration; Wnt receptor signaling pathway through beta-catenin; microtubule cytoskeleton organization and biogenesis; protein localization; cilium biogenesis; cerebral cortex radially oriented cell migration; positive regulation of cell-matrix adhesion; positive regulation of Wnt receptor signaling pathway
Research Articles on DISC1
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Product Notes
The Mouse DISC1 disc1 (Catalog #AAA9342658) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342658 ELISA Kit recognizes Mouse DISC1. It is sometimes possible for the material contained within the vial of "disrupted in schizophrenia 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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