Mouse squamous cell carcinoma antigen recognized by T cells 3 ELISA Kit | SART3 elisa kit
Mouse Squamous cell carcinoma antigen recognized by T-cells 3, SART3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SART3: a ubiquitously expressed protein in proliferating cells. A component of the 7SK snRNP complex composed of P-TEFb (composed of CDK9 and CCNT1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Transiently associates with the U6 and U4/U6 snRNPs during the spliceosome cycle, helping to regenerate functional U4/U6 snRNPs complexes. Expressed in the nucleus of all of malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas, adenocarcinomas, melanomas and leukemias. However, this protein is undetectable in the nucleus of nonmalignant cell lines or normal tissues, except for the testis. Expressed in the cytoplasm of all proliferating cells, including normal and malignant cells, but not in most cells of normal tissues, except for the testis and the fetal liver. Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Nuclear receptor co-regulator; Transcription regulation
Cellular Component: nucleoplasm; Cajal body; cytoplasm; intracellular; nucleus
Molecular Function: U6atac snRNA binding; nucleic acid binding; histone binding; RNA binding; nucleotide binding
Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; assembly of spliceosomal tri-snRNP; nucleosome assembly; regulation of gene expression; RNA splicing; cell morphogenesis; homeostasis of number of cells; mRNA processing
