TNFRSF10A recombinant protein

TNFRSF10A, 24-239aa, Human, His-tag, Baculovirus

Cat. Num. AAA206745

• Gene Names: TNFRSF10A; DR4; APO2; CD261; TRAILR1; TRAILR-1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: TNFRSF10A; 24-239aa; Human; His-tag; Baculovirus; Tumor necrosis factor receptor superfamily member 10A; APO2; CD261; DR4; TRAILR-1; TRAILR1; TNFRSF10A recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ASGTEAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSEHPG ACNRCTEGVG YTNASNNLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSRGCPR GMVKVKDCTP WSDIECVHKE SGNGHNLEHH HHHH
• Sequence Length: 468

• Applicable Applications for TNFRSF10A recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1ug of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for TNFRSF10A recombinant protein

TNFRSF10A, also known as tumor necrosis factor receptor superfamily member 10A, is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Recombinant human TNFRSF10A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for TNFRSF10A recombinant protein

Apoptosis

References

Pan G., et al, (1997) Science 276:111-113.; Kuang A.A., et al, (2000) J. Biol. Chem. 275:25065-25068.

NCBI and Uniprot Product Information

• NCBI GI #: 259906438
• NCBI GeneID: 8797
• NCBI Accession #: NP_003835
• NCBI GenBank Nucleotide #: NM_003844.3
• UniProt Accession #: O00220; Q53Y72; Q96E62; A8K5I4
• Molecular Weight: 23.9kDa (224aa) 18-28kDa (SDS-PAGE under reducing conditions)
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 10A
• NCBI Official Synonym Full Names: TNF receptor superfamily member 10a
• NCBI Official Symbol: TNFRSF10A
• NCBI Official Synonym Symbols: DR4; APO2; CD261; TRAILR1; TRAILR-1
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 10A
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 10A
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF10A
• UniProt Synonym Gene Names: APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.