Human inositol polyphosphate-5-phosphatase K ELISA Kit | INPP5K elisa kit
Human Inositol polyphosphate 5-phosphatase K, INPP5K ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Uniprot Description
INPP5K: Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; Phosphatase (non-protein); EC 3.1.3.56
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: ruffle; neuron projection; membrane; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; trans-Golgi network; nucleus; cytosol
Molecular Function: protein binding; inositol trisphosphate phosphatase activity; lipid phosphatase activity; inositol-polyphosphate 5-phosphatase activity; inositol bisphosphate phosphatase activity; vasopressin receptor activity
Biological Process: negative regulation of MAP kinase activity; negative regulation of retroviral genome replication; negative regulation of calcium ion transport; negative regulation of protein kinase B signaling cascade; negative regulation of stress fiber formation; in utero embryonic development; positive regulation of transcription, DNA-dependent; regulation of glycogen biosynthetic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of insulin receptor signaling pathway; glucose homeostasis; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; negative regulation of protein amino acid phosphorylation; cellular response to insulin stimulus; dephosphorylation; phospholipid metabolic process; negative regulation of dephosphorylation; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; actin cytoskeleton organization and biogenesis; negative regulation of glycogen biosynthetic process
Research Articles on INPP5K
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Product Notes
The Human INPP5K inpp5k (Catalog #AAA9320999) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320999 ELISA Kit recognizes Human INPP5K. It is sometimes possible for the material contained within the vial of "inositol polyphosphate-5-phosphatase K, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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