Mouse TYRO protein tyrosine kinase binding protein ELISA Kit | TYROBP elisa kit

Mouse TYRO protein tyrosine kinase-binding protein, TYROBP ELISA Kit

Cat. Num. AAA9319966

• Gene Names: Tyrobp; Ly83; DAP12; KARAP
• Reactivity: Mouse
• Synonyms: TYRO protein tyrosine kinase binding protein; Mouse TYRO protein tyrosine kinase-binding protein; TYROBP ELISA Kit; Mouse TYRO protein tyrosine kinase-binding protein (TYROBP) ELISA kit; DAP12; KARAP; PLOSL; DNAX-activation protein 12; killer activating receptor associated protein; TYROBP elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 6755915
• NCBI GeneID: 22177
• NCBI Accession #: NP_035792.1
• NCBI GenBank Nucleotide #: NM_011662.2
• UniProt Accession #: O54885; O88603
• Molecular Weight: 12,367 Da
• NCBI Official Full Name: TYRO protein tyrosine kinase-binding protein
• NCBI Official Synonym Full Names: TYRO protein tyrosine kinase binding protein
• NCBI Official Symbol: Tyrobp
• NCBI Official Synonym Symbols: Ly83; DAP12; KARAP
• NCBI Protein Information: TYRO protein tyrosine kinase-binding protein; KAR-associated protein; DNAX-activation protein 12; killer-activating receptor-associated protein; killer cell activating receptor associated protein
• UniProt Protein Name: TYRO protein tyrosine kinase-binding protein
• Protein Family: TYRO protein tyrosine kinase-binding protein
• UniProt Gene Name: Tyrobp
• UniProt Synonym Gene Names: Dap12; Karap; KAR-associated protein
• UniProt Entry Name: TYOBP_MOUSE

Uniprot Description

TYROBP: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane

Molecular Function: identical protein binding; protein binding; receptor binding

Biological Process: integrin-mediated signaling pathway; neutrophil activation during immune response; macrophage activation during immune response