Human enhancer of polycomb homolog 1 (Drosophila) ELISA Kit | EPC1 elisa kit
Human Enhancer of polycomb homolog 1, EPC1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Description
EPC1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Belongs to the enhancer of polycomb family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Acetyltransferase; Nuclear envelope
Chromosomal Location of Human Ortholog: 10p11
Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear membrane; nucleus
Molecular Function: histone acetyltransferase activity
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; regulation of growth; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on EPC1
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Product Notes
The Human EPC1 epc1 (Catalog #AAA9319733) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319733 ELISA Kit recognizes Human EPC1. It is sometimes possible for the material contained within the vial of "enhancer of polycomb homolog 1 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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