Western Blot (WB)
(Western Blot analysis of extracts of various cells, using EPC1 antibody.)
Rabbit anti-Human, Mouse EPC1 Polyclonal Antibody | anti-EPC1 antibody
EPC1 Polyclonal Antibody
Gene Names
EPC1; Epl1
Reactivity
Human, Mouse
Applications
Western Blot, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
EPC1; Polyclonal Antibody; EPC1 Polyclonal Antibody; Enhancer of polycomb 1; Enhancer of polycomb homolog 1; EPC1_HUMAN; Epl 1; Epl1; anti-EPC1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
EPC1 polyclonal antibody detects endogenous levels of EPC1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
813
Applicable Applications for anti-EPC1 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:2000
IF: 1:50-1:200
IF: 1:50-1:200
Immunogen
Recombinant full length Human EPC1.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of various cells, using EPC1 antibody.)
Western Blot (WB)
(Western Blot analysis of extracts of various cells, using EPC1 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cell using EPC1 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of HeLa cell using EPC1 antibody. Blue: DAPI for nuclear staining.)
Related Product Information for anti-EPC1 antibody
Enhancer of Polycomb 1 (EPC1) is a member of the Polycomb group (PcG) proteins. EPC1 interacts with the transcriptional repressor E2F6. In proliferating cells, the proliferation-specific PcG, EZH2, associates with this E2F6-EPC1 complex, which may regulate genes required for cell cycle promotion. EPC1 also interacts with a member of the RING finger protein family (RFP), and this complex functions as a transcriptional repressor. Lastly, EPC1 is a com-ponent of the NuA4 histone acetyltransferase (HAT) complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. This acetylation may alter nucleosome-DNA interactions and promote interaction of the modified histones with other positive transcription regulators. The HAT complex may play a role in oncogene/proto-oncogene growth induction, tumor suppressor growth arrest, replicative senescence, apoptosis and DNA repair.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 105kDa
NCBI Official Full Name
enhancer of polycomb homolog 1 isoform b
NCBI Official Synonym Full Names
enhancer of polycomb homolog 1
NCBI Official Symbol
EPC1
NCBI Official Synonym Symbols
Epl1
NCBI Protein Information
enhancer of polycomb homolog 1
UniProt Protein Name
Enhancer of polycomb homolog 1
Protein Family
UniProt Gene Name
EPC1
UniProt Entry Name
EPC1_HUMAN
NCBI Description
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Research Articles on EPC1
Similar Products
Product Notes
The EPC1 epc1 (Catalog #AAA3011349) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EPC1 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's EPC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:500-1:2000 IF: 1:50-1:200. Researchers should empirically determine the suitability of the EPC1 epc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EPC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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