Human NCK interacting protein with SH3 domain ELISA Kit | NCKIPSD elisa kit
Human NCK-interacting protein with SH3 domain, NCKIPSD ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Description
NCKIPSD: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo. In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with MLL. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Oncoprotein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21
Cellular Component: signalosome; intermediate filament; cytosol
Molecular Function: protein binding; cytoskeletal protein binding; SH3 domain binding
Biological Process: innate immune response; cytoskeleton organization and biogenesis; NLS-bearing substrate import into nucleus; signal transduction
Research Articles on NCKIPSD
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Product Notes
The Human NCKIPSD nckipsd (Catalog #AAA9318675) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318675 ELISA Kit recognizes Human NCKIPSD. It is sometimes possible for the material contained within the vial of "NCK interacting protein with SH3 domain, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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