Structure
MLT-748, Inhibitor
MLT-748
Purity
>98% (HPLC)
Synonyms
MLT-748; MLT748; MLT 748; inhibitor
Purity/Purification
>98% (HPLC)
Target
Caspase
Receptor
Caspase
Chemical Name
1-(5-chloro-6-(2H-1, 2, 3-triazol-2-yl)pyridin-3-yl)-3-(2-chloro-7-((1R, 2R)-1, 2-dimethoxypropyl)pyrazolo[1, 5-a]pyrimidin-6-yl)urea
SMILES
O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@@H](OC)[C@H](OC)C)N4C(N=C3)=CC(Cl)=N4
Molecular Formula
C19H19Cl2N9O3
CAS Number
1832578-30-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MLT-748, inhibitor
MLT-748 (MLT748) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 5nM, does not show inhibitory activity against 22 other tested human proteases (IC50>100uM); binds MALT1 in the allosteric Trp580 pocket, reversibly binds and stabilizes human mutant MALT1-W580S with Kd of 13nM, with affinity similar to that of the wild type MALT1 (Kd=42nM); stabilizes MALT1-W580S in MALT1mut/mut B cells with EC50 of 69nM, blocks cleavage of MALT1 substrates in human lymphocytes, including HOIL1, RelB, CYLD, and BCL10 (BCL10 cleavage IC50=31nM), rescues MALT1 function in patient MALT1mut/mut lymphocytes.
Product Categories/Family for MLT-748, inhibitor
References
1. Quancard J, et al. Nat Chem Biol. 2019 Jan 28. doi: 10.1038/s41589-018-0222-1.
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Product Notes
The MLT-748 (Catalog #AAA3602826) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MLT-748, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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