Human scribbled homolog (Drosophila) ELISA Kit | SCRIB elisa kit
Human Protein scribble homolog, SCRIB ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
Scribble: may be involved in regulating neuroblast cortical polarity, cell size asymmetry and mitotic spindle asymmetry. A neoplastic tumor suppressor genes in Drosophila melanogaster. May play a role in the suppression of mammalian tumorigenesis. Gene ablation in the mouse causes severe neural tube defects. May be implicated in the etiology of human NTDs. Involved in the regulation of synaptic plasticity and synaptic vesicle dynamics. May be required to sustain synaptic vesicle concentrations at their sites of release. Targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein.
Protein type: Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: presynaptic membrane; nucleoplasm; postsynaptic membrane; cell-cell adherens junction; lamellipodium; basolateral plasma membrane; leading edge; plasma membrane; intercellular junction
Molecular Function: protein binding
Biological Process: cell migration; wound healing; viral reproduction; positive regulation of apoptosis; establishment of apical/basal cell polarity; cochlear nucleus development; asymmetric protein localization; cell proliferation; cell-cell adhesion; positive chemotaxis; neural tube closure; synaptic vesicle endocytosis; negative regulation of mitotic cell cycle; auditory receptor cell stereocilium organization and biogenesis; synaptic vesicle targeting; positive regulation of receptor recycling; astrocyte cell migration
Research Articles on SCRIB
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Product Notes
The Human SCRIB scrib (Catalog #AAA9317650) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317650 ELISA Kit recognizes Human SCRIB. It is sometimes possible for the material contained within the vial of "scribbled homolog (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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