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PHB2 (Y248) Blocking Peptide | PHB2 blocking peptide

PHB2 Blocking Peptide (Y248)

Gene Names
PHB2; BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141
Synonyms
PHB2 (Y248); PHB2 Blocking Peptide (Y248); Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity; PHB2; PHB2 blocking peptide
Ordering
Specificity
The synthetic peptide sequence is selected from aa 240-255 of HUMAN PHB2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
261
Cellular Location
Mitochondrion inner membrane. Cytoplasm. Nucleus. Note: Also cytoplasmic and nuclear.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for PHB2 blocking peptide
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
29,044 Da
NCBI Official Synonym Full Names
prohibitin 2
NCBI Official Symbol
PHB2
NCBI Official Synonym Symbols
BAP; REA; p22; hBAP; Bap37; BCAP37; PNAS-141
NCBI Protein Information
prohibitin-2
UniProt Protein Name
Prohibitin-2
Protein Family
UniProt Gene Name
PHB2
UniProt Entry Name
PHB2_HUMAN

Uniprot Description

BAP37: a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Mitochondrial

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cell surface; cytoplasm; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; nuclear matrix; nucleus; protein complex

Molecular Function: amide binding; protein binding; protein C-terminus binding; protein N-terminus binding

Biological Process: mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of exit from mitosis; positive regulation of transcription factor activity; protein import into nucleus, translocation; protein stabilization; regulation of complement activation; sister chromatid cohesion

Research Articles on PHB2

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Product Notes

The PHB2 phb2 (Catalog #AAA9230919) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PHB2 (Y248), Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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